The secondary metabolites have been identified in plants as alkaloids, terpenoids, phenolics, anthraquinones, and triterpenes
They can also experience focal onset seizures, which tend to be shorter and may include repetitive movement of the arms or legs, lip smacking and chewing
Ambery PD, Klammt S, Posch MG et al (2018) MEDI0382, a GLP-1/glucagon receptor dual agonist, meets safety and tolerability endpoints in a single-dose, healthy-subjects, randomized, phase 1 study
Fase-2-obesitasstudie (NEJM, 2023): bij volwassenen met obesitas/overgewicht leidde retatrutide tot gemiddeld ~17,5% gewichtsverlies op 24 weken en tot ~24% op 48 weken (secundaire uitkomst)
Humans can lose a lot of fat without negative consequences (except for effects on overdosing on anti-hypertensive meds) BUT losing muscle has profound negative impact
Although clinical research indicates the greater overall benefits of semaglutide, the choice between the two may be influenced by factors such as researcher health and cost
