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p = 0.002) and waist circumference (AOR = 2.5

Ethics statement The animal study was reviewed and approved by the Laboratory Animal Welfare and Ethics Committee of Fourth Military Medical University

Whilst significant alterations in OCR and ECAR were demonstrated in normal rectal tissue biopsies treated with H 2 O vehicle control versus baseline, interestingly, no significant alterations in OCR or ECAR was demonstrated following metformin treatment, when compared to baseline ( Figures 6C, D )

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Chapman LE, Darling AL, Brown JE (2015) The association between the biguanide drug metformin and vitamin B 12 deficiency in diabetic patients: a systematic review