Yilan Huang, [email protected] These authors share first authorship These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
Since NAD+ metabolism generates NADPH for glutathione recycling, and glutathione protects against oxidative damage that depletes NAD+, maintaining both creates a reinforcing cycle of cellular protection
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Ref.: Imai & Guarente, Trends Cell Biol 2014 | Katsyuba et al., Nat Metab 2020 Glutathione is an endogenous tripeptide (gamma-Glu-Cys-Gly) and the main intracellular antioxidant in the human body
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