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Lethal neonatal deficiency of carnitine palmitoyltransferase II associated with dysgenesis of the brain and kidneys

For a flexible or non-rigid protein, the intrinsic fluorophores (tryptophan residues) have freedom to rotate independently of the rest of the molecule

We therefore conclude that before the place of GLP-1/glucagon co-agonists within the therapeutic armamentarium can be defined, future research efforts need to address the following outstanding questions: What is the optimal balance and receptor potency of GLP-1 and glucagon in a long-acting co-agonist, to minimise adverse effects and to optimise efficacy ( Figure 2 )

Instead of taking a drug to slow dietary carbohydrate digestion, what about just choosing a diet centered around slow-digesting lente carbohydrates to achieve comparable benefits

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(2023, October 4)