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EV surface ligand-receptor interactions likely vary across different EV populations, involving integrins, sugar chains, lectins, phosphatidylserine, tetraspanins, and cell adhesion molecules 57

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Notably, surveys of patients with ME/CFS indicate that they are more likely to try supplement use autonomously rather than in consultation with a clinician

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53,104,105,106 Bi-layered scaffolds derived from articular cartilage ECM and growth plate ECM can be used to regenerate osteochondral tissue with better recapitulation of the native architecture