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Dose-finding study of subcutaneously administered BI 456906 for 16 weeks, compared with placebo and open-label semaglutide in patients with type 2 diabetes mellitus

Reduce Appetite GLP-1 receptors in your brain signal satiety, which means you naturally eat less without feeling deprived

The above results suggested that GLP-1R increases the expression levels of ABCA1, and it was therefore hypothesized that the effects of GLP-1R on ASM cell proliferation, migration and cytokine release are dependent on altered ABCA1 expression levels

Phase 2 trial in type 2 diabetes (Lancet 2023) showed similar additive benefit for the combination

The GIP receptor plays an important role in regulating insulin and appetite, providing an additional mechanism for improved blood sugar control and appetite suppression

Staying hydrated, trying to eat smaller meals more often and following the nausea tips listed above