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Research suggests GIP can enhance GLP-1's effects on insulin secretion through synergistic pancreatic effects, and may provide metabolic benefits including bone health preservation during weight loss and maintenance of energy expenditure

DM patients often showed early asymptomatic increased left ventricular (LV) stiffness, accompanied by abnormal natriuretic peptide (ANP) signal, which was the early phenomenon of HFpEF [26, 27]

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