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In the analysis of the effect of MEDI7219 on body weight in HFHF fed dogs, one animal in the placebo group and one datapoint on day 10 in the MEDI7219 group were excluded due to errors in measurement

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GLP-1 therapy typically produces 1015% body weight loss over 612 months, which translates to an average 1015 mmHg systolic blood pressure reduction in responders

3.9 Absence of cytotoxic effects in mice treated with GO@GSH-FA Hematoxylin and Eosin (H.E.) stained tissue sections from various organs of mice treated with GO@GSH-FA were examined to assess potential cytotoxic effects (Figure 9)