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In two single-arm, open-label clinical trials comprising 37 children with MLD, Lenmeldy significantly reduced the risk of severe motor impairment or death compared with untreated children, according to the FDAs press release

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intra-articular injection directly into the joint (physician-administered, for knee, shoulder, wrist, and hip conditions)

For practical research-design reference, a serum half-life estimate of 1-4 hours (IP administration) is a reasonable working assumption, though with substantial uncertainty

Everard A, Belzer C, Geurts L et al (2013) Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity