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The An 2019 clinical trial in Annals of Dermatology tested a crosslinked hyaluronic acid microneedle patch loaded with sh-Oligopeptide-1 and Acetyl Hexapeptide-8 against vehicle control in Korean women with peri-orbital wrinkles, and found significant reductions in wrinkle depth and improvements in skin elasticity over 8 weeks [37]
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a neuromodulator that has strong brand recognition, even among those unfamiliar with facial rejuvenation
Nephron Exp Nephrol 2012;122:2335
These findings align with a model in which ERR activation restores mitochondrial oxidative capacity and lipid flux in hepatocytes, contributing to reversal of steatotic features
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