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used a neutralizing antibody of ANGPTL4 in both humanized mice and nonhuman primates, which resulted in severe side effects and systemic metabolic abnormalities (Dewey et al., 2016)

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The relatively long half-life enables convenient once-weekly dosing while maintaining consistent appetite suppression between injections

Because demand for GLP-1 medications remains high, some physicians worry the change could push patients toward unregulated or international sources

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