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doi: 10.1016/j.ecoenv.2020.111426

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Together, our findings support that TGF 1 is driving BBB permeability via downregulation of claudin-5 and upregulation of MMP9 and that these effects are dependent on SMAD3

In the context of a herniated disc, the surrounding spinal muscles often go into a state of chronic spasm and can even atrophy from disuse or nerve signal interruption