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it does not constitute a dosing recommendation, and the absence of an established human injection dose in this article reflects the actual state of the peer-reviewed literature

A small pilot study in 20 human patients (aged 5075, with obesity and knee osteoarthritis) found that those receiving semaglutide alongside standard treatment showed an average 17% increase in cartilage thickness on MRI after 24 weeks, compared to less than 1% in the control group