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ArticlePubMed [41] Gao Q, Tian W, Yang H, Hu H, Zheng J, Yao X, et al

The nuclear pore-associated TREX-2 complex employs mediator to regulate gene expression

These are associated with inducing liver stress and inflammation

Despite this exciting potential, efforts to develop an amylin-based anti-obesity therapeutic stalled owing to challenges around dosage frequency, safety and formulation