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Similar content being viewed by others Introduction Parkinsons disease (PD) is a progressive neurodegenerative disease characterized by resting tremor, bradykinesia, rigidity, and loss of postural reflexes that pathologically manifests as loss of dopaminergic neurons in the substantia nigra (SN) and intracellular Lewy body deposition 1

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doi:10.1016/j.biopsych.2004.11.006 McLaughlin KA, Fox NA, Zeanah CH, Sheridan MA, Marshall P, Nelson CA