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We however think that GLP-1RAs should be avoided in people with HF with reduced ejection fraction until robust evidence of benefit is generated in this group

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The main difference is that tirzepatide tends to produce more significant appetite suppression due to its dual-receptor mechanism, so semaglutide users may find they can tolerate slightly larger portions

Low Blood Sugar Tirzepatide improves blood sugar control, but it can increase the risk of low blood sugar when used with insulin or sulfonylureas

J Am Heart Assoc

The enhanced contact can also block ion migration pathways at the interface