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Many candidates also experience persistent cravings, insulin resistance, or metabolic slowdown that GLP-1 therapy may help address

Similarly, green tea extract (which carries rare but serious liver injury risk at high doses) and cinnamon (particularly cassia cinnamon, which contains coumarin) have been studied for metabolic effects, but there is no robust evidence they meaningfully enhance incretin hormone activity in humans

In 2021, diabetes was responsible for 6.7 million deaths, and it is projected that by 2045, the number of individuals with diabetes will increase to 783 million, highlighting the growing global burden of T2DM over the coming decades (Sun et al., 2022)

Also, no signs of increased CVD risk were observed

The study aims to investigate how endogenous GLP-1 signaling affects joint health and how it could be used to treat arthritis