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Figure 1 shows the PRISMA flowchart
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2 Before the GLP-1 era: the traditional treatment pathway and its limitations Before the emergence of GLP-1-based anti-obesity pharmacotherapy, obesity-related KOA was generally managed within the same stepwise framework used for KOA overall, although overweight or obesity was explicitly recognized as a modifiable therapeutic target
This structure reflects the general pattern seen across this kind of titration schedule used in clinical settings, though a provider may pause an increase or extend a stage if a patient experiences nausea, stomach upset, or other digestive symptoms
