Chen, X
Mounjaro (tirzepatide) works similarly to GLP-1 and GIP to help you lose weight by lowering your appetite
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Estradiol also decreases appetite directly by increasing anorexigenic gene expression in POMC neurons and decreasing the expression of orexigenic genes in NPY/AgRP neurons (84, 86)
So, you may have difficulty maintaining your weight loss due to harmful gut organisms that have taken hold
10.1074/jbc.M000120200