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Endothelial-derived impaired PDGFR signaling results in microvascular reductions, decreased CBF, and accumulation of neurotoxic molecules from the blood, contributing to secondary neurodegeneration [45, 74]

146,147,148 Tuberous sclerosis is an autosomal dominant disorder arising from heterozygous mutations in the TSC1 and TSC2 genes that is commonly associated with deficits in long-term and working memory, intellectual disability, and ASD

The amount of ozone in this is smaller, but the effect is larger because its continuous

Participants had a mean age of 57.4 years (25.8% were aged 65 or above), with 54.2% identifying as male and 78.6% as White [58]

Scand J Clin Lab Investig 81(2):116120 Dawson EB, Evans DR, Nosovitch J (1999) Third-trimester amniotic fluid metal levels associated with preeclampsia