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Linker chemistry plays a critical role, where disulfide (SS) or diselenide (SeSe) bonds connect the drug to the carrier, enabling selective cleavage under reducing conditions

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doi: 10.1007/bf03401781 102 ZhangZKollsJKOliverPGoodDSchwarzenbergerPOJoshiMSet al

In a study of triple-negative breast cancer (TNBC), it was found that when combined with the SLC7A5 blocker JPH203 and an anti-programmed cell death 1 (PD-1) antibody, it significantly inhibited cell proliferation, invasion, and migration, increased infiltration of CD8 + T cells, and suppressed tumor immune escape [106, 107]