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Not all HRT formulations carry the same risk profile, and those differences are clinically significant in the context of the cardiometabolic goals this combination approach is designed to serve

The co-formulation creates a more robust and impenetrable barrier to DNA synthesis entry, effectively trapping cancer cells in a state where repair is futile and progression is blocked, ultimately committing them to programmed cell death

Patients report benefits fade within 2-6 months after stopping treatment

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