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Steegers-Theunissen RP, Obermann-Borst SA, Kremer D, et al

reported that among 18,507 participants with no history of hospitalization due to heart disease or stroke and who were known not to be pregnant, the median GDF15 level was 816 pg/mL in women and 793 pg/mL in men

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Activation couples to Gs, raises intracellular cyclic AMP, and engages protein kinase A