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In PTC, high level of phosphoglycerate dehydrogenase (PHGDH), which catalyzes the process producing the precursor of serine as well as the first key enzyme of one-carbon metabolism, facilitates TC progression [160, 161]

But I'll ask first

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They are fundamentally different

Mourelle ML, Segura de Yebra J, Ayats J, Vitale M, Lpez Snchez A (2024) Potential Benefits of a Cosmetic Ingredient Combining Thermal Spring Water and Diatom Algae Extract