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HTT-lowering reverses Huntingtons disease immune dysfunction caused by NFB pathway dysregulation

Diphenylpicrylhydrazyl GC-FID: Gas chromatography-flame ionization detector GCMS: Gas chromatography-mass spectrometry HepG2: Human hepatocellular carcinoma ESI-HRMS: Electrospray ionization/high resolution-mass spectrometry ER + : Estrogen receptor-positive breast cancer cells HPLC: High-performance liquid chromatography EO: Essential oil MTT: Dimethylthiazol-diphenyltetrazolium bromide TLC: Thin-layer chromatography HPLCMS: High Performance liquid chromatography coupled with mass spectrometry IC 50 : Median inhibition concentration HSV-1: Herpes Simplex virus (type 1) FRAP: Ferric-reducing power assay IL: Interleukin QE: Quercetin equivalent LCMS/MS: Liquid chromatography/tandem mass spectrometry MIC: Minimum inhibitory concentration NF-B: Nuclear factor-kappa B NO: Nitric oxide PPAR-: Peroxisome proliferator-activated receptors- NMR: Nuclear magnetic resonance PGE 2 : Prostaglandin E 2 SFE: Supercritical fluid extraction TBA: Tiobarbituric acid UAE: Ultrasound assisted extraction TNF-: Tumor necrosis factor alpha VEGF: Vascular endothelial growth factor References Achak N, Romane A, Alifriqui M, Adams RP (2009) Chemical studies of leaf essential oils of three species of Juniperus from Tensift Al Haouz-Marrakech region (Morocco)

Brain 136 , 891904, (2013)

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Afterwards, the cells were cultured in serum-free medium containing 1 mM H 2 O 2 for 12 h