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A prototypical example is the Zellweger spectrum disorders (ZSD), which arise from mutations in PEX genes encoding RING-type zinc finger peroxins such as PEX12 and PEX10, whose zinc-coordinating motifs are essential for peroxisome assembly and protein import 159,160

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10.1002/ijc.23755 71 OdagiriN.MatsubaraT.Sato-MatsubaraM.FujiiH.EnomotoM.KawadaN

The effect of topical tripeptide-copper complex on healing of ischemic wounds in rats

Because the goal is local gut exposure, the oral route is most often selected specifically when the gut is the target rather than as a substitute for systemic delivery

It plays a critical role in overall physiological health