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TRT raises testosterone directly
As stated before, glutathione is the most abundant antioxidant in the cell, with a key role in ROS scavenging in cancer cells
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Accordingly, disrupted interactions between the gut microbiota and bile acids impair intestinal barrier function and activate inflammation-related signaling pathways, exacerbating the progression of IBD
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In diabetic nephropathy, podocyte NOX4derived HO drives podocyte injury and slit-diaphragm defects, thereby promoting albuminuria [345], whereas in diabetic retinopathy PKC-driven and VEGF-driven permeability changes are tightly linked to oxidative stress [346]
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