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The test material exposure time was chosen based on the average time (30 min) for which the upper airway mucociliary beating transport mechanism propels inhaled particles out of the human airways (Koparal et al., 2021), and previous experimental design in which MucilAir systems were daily exposed to inhaled drugs for 6 h over 12-day period (Balogh Sivars et al., 2017)

Glyoxylases (Glo) The glyoxalase system is a ubiquitous enzymatic network present in the cytoplasm, and some of them are also in the nucleus