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The gradual titration schedule helps minimize early side effects, and most patients who complete the titration phase tolerate the medication well long-term

The average concentration of 2M in human plasma is 1.3 M and there is evidence that 2M can bind copper ions and participate in copper delivery into mammalian cells 18

Acknowledgements The authors would like to thank the experimental apparatus and technical support provided by the Key Laboratory for Metabolic Diseases in Chinese Medicine, Nanjing University of Chinese Medicine

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Linda Bluestein: That's really good, because we know that a lot of people with POTS do have problems with sexual function, and that can be so impactful on your overall wellbeing

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