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A mild concussion with intact blood-brain barrier presents a very different repair challenge than a severe TBI with diffuse axonal injury and widespread inflammation
Jalleh RJ, Plummer MP, Marathe CS, Umapathysivam MM, Quast DR, Rayner CK, Jones KL, Wu T, Horowitz M, Nauck MA (2024) Clinical consequences of delayed gastric emptying with GLP-1 receptor agonists and tirzepatide
SURMOUNT-1 Trial (72-Week Duration, 2,539 Participants): Average weight loss with 15 mg: 20.9% of body weight Participants losing 5%: 91% Participants losing 10%: 82% Participants losing 20%: 57% SURMOUNT-2 Trial (People with Type 2 Diabetes): Average weight loss with 15 mg: 15.7% A1C reduction: 2.0 percentage points Source: Jastreboff AM, et al
Understanding injectable versus oral peptide bioavailability is particularly important for brain-targeted protocols
When given intravenously (10-20 mg/kg body weight), the daily dose of glutathione recommended for adults varies between 500 and 2,000 mg
