People who significantly decrease their weight - whether through GLP-1s, behavioral programs or bariatric surgery - often lose muscle mass at the same time
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As a defined small molecule (not a peptide), it has different handling considerations than the rest of the Durham Peptides catalog, but the research utility is in the same conceptual category as NAD+-pathway research compounds
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Collectively, this suggests the need for increased molecular profiling of tumors for rational selection of targeted therapies and immunotherapy agents to improve local control of BM, particularly in radioresistant cancers such as melanoma (Table 2)
Classical EDS patients, who share joint hypermobility features, likely stand to gain similarly from these therapies in managing their musculoskeletal issues (though care must be taken with their fragile skin during injections)