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In the published clinical literature on the reference drug (for example the STEP-1 extension study of semaglutide), discontinuing a GLP-1 receptor agonist is followed by the return of appetite signalling and gradual regain of much of the lost body weight over roughly a year, because the receptor stimulation that slowed gastric emptying and curbed appetite is withdrawn

To assist readers in comparing key offerings in the GLP-1 telehealth weight management space, the following table highlights the distinctions across various platforms

doi: 10.1016/j.tox.2004.09.002

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However, GLP-1R stimulation may induce adverse responses