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One of the most promising strategies to overcome this multi-drug resistance, MRP1-mediated CS, relies on the ability of certain ligands of MRP1 to induce a massive MRP1-dependent GSH efflux, that depletes the cells of their anti-oxidant defense, leading to their selective cell death 15

doi: 10.1073/pnas.0400181101

Molecular and biochemical mechanisms in teratogenesis involving reactive oxygen species

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