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The delayed gastric emptying from GLP-1 can, however, affect the metabolism and efficacy of certain oral sedatives, as well as precipitate an increased risk of aspiration under twilight sedation

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Patients with a stressed myocardium should be observed carefully and the drug administered slowly since premature ventricular contractions may occur with rapid administration

That's according to a recent survey from Evercore ISI focused on GLP-1s, a new class of medications used to treat Type 2 diabetes and obesity

5.3 Safety and off-target effects Modulating the immune system and mitochondria can have unintended consequences