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Gut microbial metabolites in obesity, NAFLD and T2DM
DOI: Published online: May 1, 2025 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea 2 Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea Corresponding author: Jae Hyun Bae Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul 03080, Korea E-mail: [email protected] Copyright 2025 Korean Diabetes Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited
Patients with higher baseline body mass index (BMI) or more severe insulin resistance may experience different response patterns compared to those with milder metabolic dysfunction
The question now is long-term commitment to maintaining these results
Meta-analyses suggest a small but statistically significant effect on body weight, with average reductions of 1-2 kg over 12 weeks