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You notice persistent, unexplained dizziness or fatigue that worsens after taking supplements

Laboratory studies have extensively characterized glutathione's role in phase II metabolism, where it conjugates with reactive drug metabolites and environmental toxicants via glutathione S-transferases, a pathway central to pharmacology and toxicology research

However, in individuals with compromised glutathione status, the body generates more NAPQIthe toxic metabolite that crosses the placenta, depletes fetal brain glutathione, and damages developing neurons

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NGS reads were mapped to the Genome Reference Consortium GRCh38 assembly via Spliced Transcripts Alignment to a Reference (STAR, v2.7.9a) (Dobin et al, 2013) using the basic GENCODE transcript annotation from version 43 (February 2023) (Frankish et al, 2021) as a reference transcriptome

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