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The surfactants Vit-E-PEG, AOT, polysorbate 80, CTAB, polysorbate 20, Cremophor EL, Solutol HS 15, and Brij 58 and the polymer NaCMC have been shown to be inhibitors of P-glycoprotein (P-gp) in MDCK-MDR1 cell culture, as determined by significant intracellular increase in digoxin (41)

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sobre la clula beta del pncreas, estimulando la secrecin rpida e inicial de insulina previo a la absorcin de glucosa y disminuyendo la descarga de glucagn en el perodo postprandial (Fig