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Cruciani RA, Dvorkin E, Homel P, et al

[63] found that the enzyme dihydroorotate dehydrogenase (DHODH) and mitochondrial GPX4 constitute two additional defense enzymes that can detoxify lipid peroxides in the mitochondria

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Its important to follow the dosing schedule for this medication carefully to match study protocols and ensure consistent results

Zhonghua Yi Xue Za Zhi Chin Med J Free China Ed 57:100105 Wang WS, Tzeng CH, Chiou TJ et al (1997) High-dose cytarabine and mitoxantrone as salvage therapy for refractory non-Hodgkins lymphoma