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Blockade of the VEGF/VEGFR signaling pathway can aggravate hypoxia resulting in the upregulation of alternative angiogenic factors such as PDGFs, FGFs, chemokines, interleukin-8 (IL-8), Delta-like ligand-4, and ephrins (Lord and Harris, 2010

10.1371/journal.pcbi.1003330 144 ZhangW.LindenD

The FDA will consider the panels advice, along with the agencys own scientific review and other regulatory factors, before making a final determination