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As we previously demonstrated, acivicin at these concentrations did not elicit oxidative stress or affect cell viability (16)

Materials and Methods Cell culture and reagents Dissociated cortical neuron cultures from Sprague-Dawley rats were prepared as described previously (62)

10.1016/j.mito.2016.06.006 111

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Because KPV apparently curbs NF-B and MAPK signaling and lowers pro-inflammatory cytokine release, it may help create conditions under which fibroblast activity and matrix deposition may continue with less inflammatory interference