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J Exp Med 179(5):14091415 Ha H, Debnath B, Neamati N (2017) Role of the CXCL8-CXCR199/2 axis in cancer and inflammatory diseases

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RGD-GHK also exhibited strong anti-senescent properties in human and mouse embryonic fibroblasts, as well as in vitro wound-healing properties and the ability to repair the skin barrier

Neither peptide is approved by the FDA or comparable regulators as a hair-loss treatment, and neither has completed a human efficacy trial for that purpose

In vitro and mechanistic studies (weakest for clinical conclusions) Cell culture studies showing peptides protecting retinal cells from various insults (oxidative stress, glucose toxicity, inflammatory cytokines, hypoxia)

hCG was also shown to upregulate the expression of IGFR in rat Leydig cells suggesting cross-talk between both pathways (90, 103)