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By week 8, most users see minimal additional progress

In patients undergoing cardiac surgery, EAT exhibits intense inflammation, fibrosis, angiogenesis, and apoptosis and can affect the adjacent myocardium through paracrine mechanisms or direct cellular infiltration (1820)

Crucially, follow-up data from these trials show that most participants (about two-thirds) regain a significant amount of weight and lose many of the improvements in metabolic health when they stop using the drugs

There is a lot of discussion about people potentially taking GLP-1s for life for the cardiovascular health benefits

The real issue is invisible degradation

Endocrinology 166 (4), bqaf028