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It has been suggested that a level below 200ng/L is appropriate to diagnose deficiency in most cases

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[5] Cyanocobalamin is stable, cost-effective to manufacture, and has a long shelf life

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However, Mdv1 has not been detected in mammalian cells (Stojanovski et al., 2004), where FIS1 is required to interact with additional outer membrane receptors, including Mff, MID49, and MID51, to facilitate Drp1 polymerization and assembly into a helical or ring structure surrounding the mitochondrial outer membrane, thereby recruiting Drp1 to the division site, which ultimately initiates fission (Takamura et al., 2012)