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however, the largest cluster included only two mice from the 5A-1MQ-treated group switched from WD to LD

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Additional transformations, including oxidation and epimerization of hydroxyl groups at positions C3, C7 and C12, mediated by microbial hydroxysteroid dehydrogenases (HSDHs) from genera such as Eubacterium , Ruminococcus and Bacteroides , further diversify the bile acid pool and its receptor pharmacology [82]

Trying to fill your way out of surgical-level laxity often backfires," he explains