For tablets (Rybelsus), absolutely yes
As shown in Table 1 [1,8,12-19] , because of the critical role of this pathway in energy regulation, functional abnormalities caused by mutations in any of its critical genes (e.g., LEP , LEPR , POMC , PCSK1 , MC4R ) can lead to severe early-onset obesity and extreme hyperphagia and are often accompanied by endocrine abnormalities due to deficiencies in related hormones, such as hypogonadism and hypothyroidism [12,20]
Frontiers in Microbiology, 12 , 639948
Greig, he's from NIH or from NIA, I can't remember, right
The flat-rate structure also insulates you from the single biggest cost surprise on this list: dose-tier escalation
Our food environment drives weight gain Foods high in salt, sugar and fat that are "highly palatable and energy dense" are pretty much everywhere and our brain chemistry drives us to consume them, says Kessler