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10.37765/ajmc.2021.88714 237

OUD participants were also current smokers ( n = 8), current marijuana users ( n = 7), current ( n = 4) or past ( n = 3) cocaine users, current ( n = 2) or past ( n = 1) amphetamine users, and past LSD users ( n = 2)

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Additionally, activation of the PI3K/AKT signaling pathway results in the aberrant production of various downstream effector molecules that have anti-apoptotic and pro-survival effects

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While it may help increase natural testosterone in men with obesity-related low T, men with primary hypogonadism or clinically documented testosterone deficiency still require TRT for adequate hormone restoration