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Functional studies in neurons and cell lines under physiologic conditions, again utilizing voltage-gated calcium channel modulation by MOR, have also failed to detect constitutive MOR activity after chronic exposure to morphine in locus coeruleus (Connor et al., 1999) and periaqueductal gray neurons (Bagley et al., 2005b) or ShSY5Y cells (Kennedy and Henderson, 1992)

Proc Natl Acad Sci USA 86:73217325 [DOI] [PMC free article] [PubMed] [Google Scholar] Costa T, Cotecchia S

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[4] Second, glycine is added to the C-terminal of -glutamylcysteine

Decisions regarding therapy resumption should involve a careful risk-benefit discussion with a qualified healthcare professional

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