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Clinical trials demonstrate tirzepatide produces 2025% body weight reductions in patients who plateau on semaglutide, particularly those with genetic variants favoring dual-pathway activation

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Starting doses on the lower end (300mcg) and progressing slowly makes sense

doi: 10.3389/fonc.2026.1740352 Received 05 November 2025 Revised 28 December 2025 Accepted 13 January 2026 Published 30 January 2026 Volume 16 - 2026 Edited by Felipe DAlmeida Costa, A

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