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The weight-drop, midline fluid percussion, and controlled cortical impact models produce focal contusions and, depending on injury severity, may be associated with subarachnoid and intraparenchymal hemorrhages, disruption of the blood-brain barrier (BBB), cortical and subcortical cell loss, and diffuse axonal injury

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The two strands of a miRNA duplex may be designated with the suffix -5p (originating from the 5' side of the pre-miRNA), or -3p (from the 3' side) [10]

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Some peptides might be well tolerated, but there is risk and unknowns