SGLT2 inhibitors have exhibited better effects regarding a reduced incidence of HF, whereas GLP-1-R agonists have shown a reduced risk of CV events, particularly stroke
A review of the evidence on cardiovascular outcomes from obesity treatment
Psychoneuroendocrinology 38, 12591270
Characterized by insulin resistance, gradual progressive loss of insulin secretion by -cells, and being heavily driven by being overweight or obese [98], T2DM leads to hyperglycemia, excessive urine production, increased risk of cardiovascular disease, and changes in energy metabolism [106]
While there are long-term health benefits and related savings for people taking GLP-1s, most employers and health plans that paid for the upfront costs dont actually benefit when people change jobs every four years
Emerging evidence suggests that GLP1 therapy can: Reduce hepatic fat content, as shown in MRI-PDFF studies Lower markers of liver inflammation and fibrosis Improve insulin sensitivity and metabolic control Although most trials focus on obese or diabetic populations, livercentric endpoints are increasingly evaluated, and benefits appear to extend beyond weight loss alone